Product Data Sheet
hnNOS-IN-3
Catalog No. A65177
hnNOS-IN-3 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki value of 0.32 μM, demonstrating competitive binding with L-arginine. This compound exhibits remarkable selectivity, with 115-fold increased affinity for nNOS over inducible nitric oxide synthase (iNOS, Ki=37 μM) and 29-fold greater affinity over endothelial nitric oxide synthase (eNOS, Ki=9.4 μM). hnNOS-IN-3 serves as a valuable tool for studying nNOS-related biological processes and potential therapeutic interventions in neurological disorders.
Chemical Information
| Catalog Num | A65177 |
|---|---|
| M. Wt | 284.73 |
| Formula | C10H12ClF3N2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 163490-78-6 |
| Synonyms | |
| SMILES | N=C(SCC)NC1=CC=C(C(F)(F)F)C=C1.[H]Cl |
Biological Activity
| Description | hnNOS-IN-3 is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki value of 0.32 μM, demonstrating competitive binding with L-arginine. This compound exhibits remarkable selectivity, with 115-fold increased affinity for nNOS over inducible nitric oxide synthase (iNOS, Ki=37 μM) and 29-fold greater affinity over endothelial nitric oxide synthase (eNOS, Ki=9.4 μM). hnNOS-IN-3 serves as a valuable tool for studying nNOS-related biological processes and potential therapeutic interventions in neurological disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
