Product Data Sheet
L-NIO
Catalog No. A65226
L-NIO is a potent, non-selective nitric oxide synthase (NOS) inhibitor that acts by inhibiting the NADPH-dependent activity of the enzyme. It displays inhibition constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms, respectively. L-NIO has been shown to induce focal ischemic infarcts in rat models, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. Its ability to effectively modulate NOS activity positions it as a significant reagent in cardiovascular and neurobiological research applications.
Chemical Information
| Catalog Num | A65226 |
|---|---|
| M. Wt | 173.21 |
| Formula | C7H15N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 36889-13-1 |
| Synonyms | |
| SMILES | CC(NCCC[C@@H](C(O)=O)N)=N |
Biological Activity
| Description | L-NIO is a potent, non-selective nitric oxide synthase (NOS) inhibitor that acts by inhibiting the NADPH-dependent activity of the enzyme. It displays inhibition constants (Kis) of 1.7, 3.9, and 3.9 μM for neuronal (nNOS), endothelial (eNOS), and inducible (iNOS) isoforms, respectively. L-NIO has been shown to induce focal ischemic infarcts in rat models, making it a valuable tool for studying the role of nitric oxide in various physiological and pathological processes. Its ability to effectively modulate NOS activity positions it as a significant reagent in cardiovascular and neurobiological research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
