Product Data Sheet
Estetrol-d4 (Major)
Catalog No. A65299
Estetrol-d4 (Major) is a deuterium-labeled derivative of Estetrol, a selective nuclear estrogen receptor modulator primarily synthesized by the human fetal liver during pregnancy. Estetrol demonstrates affinity for estrogen receptors ERα and ERβ, enhancing eNOS expression and nitric oxide synthesis in endothelial cells. Its estrogenic effects are noted in the endometrium and central nervous system, while exhibiting antagonistic properties in breast tissue. This reagent is valuable in research applications involving contraception and menopausal hormone therapy studies.
Chemical Information
| Catalog Num | A65299 |
|---|---|
| M. Wt | 308.41 |
| Formula | C18H20D4O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2734920-42-2 |
| Synonyms | |
| SMILES | [2H]C1=C(C([2H])=C(C2=C1)C([2H])(C[C@@]3([C@@]2(CC[C@]4([C@]3([C@H]([C@H]([C@@H]4O)O)O)[H])C)[H])[H])[2H])O |
Biological Activity
| Description | Estetrol-d4 (Major) is a deuterium-labeled derivative of Estetrol, a selective nuclear estrogen receptor modulator primarily synthesized by the human fetal liver during pregnancy. Estetrol demonstrates affinity for estrogen receptors ERα and ERβ, enhancing eNOS expression and nitric oxide synthesis in endothelial cells. Its estrogenic effects are noted in the endometrium and central nervous system, while exhibiting antagonistic properties in breast tissue. This reagent is valuable in research applications involving contraception and menopausal hormone therapy studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
