Product Data Sheet
1,3-PBIT dihydrobromide
Catalog No. A65318
1,3-PBIT dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a Ki value of 47 nM. In contrast, it shows reduced inhibition for endothelial (eNOS) and neuronal nitric oxide synthase (nNOS), with Ki values of 9 µM and 0.25 µM, respectively, for purified human enzymes. While it effectively inhibits iNOS in vitro, its cellular activity may be limited by membrane permeability, making it primarily useful for biochemical studies on nitric oxide pathways and their related regulatory mechanisms.
Chemical Information
| Catalog Num | A65318 |
|---|---|
| M. Wt | 444.25 |
| Formula | C12H20Br2N4S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 200716-66-1 |
| Synonyms | |
| SMILES | NC(SCCC1=CC(CCSC(N)=N)=CC=C1)=N.Br.Br |
Biological Activity
| Description | 1,3-PBIT dihydrobromide is a selective inhibitor of inducible nitric oxide synthase (iNOS), demonstrating a Ki value of 47 nM. In contrast, it shows reduced inhibition for endothelial (eNOS) and neuronal nitric oxide synthase (nNOS), with Ki values of 9 µM and 0.25 µM, respectively, for purified human enzymes. While it effectively inhibits iNOS in vitro, its cellular activity may be limited by membrane permeability, making it primarily useful for biochemical studies on nitric oxide pathways and their related regulatory mechanisms. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
