Product Data Sheet
AF3485
Catalog No. A65420
AF3485 is an inhibitor of the human microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating significant antitumor activity both in vitro and in vivo. This compound effectively targets tumor-associated angiogenesis by lowering prostaglandin E2 (PGE2) levels, inhibiting epidermal growth factor receptor (EGFR) signaling, and decreasing the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Subchronic administration of AF3485 has been shown to reduce tumor growth in mice with human A431 xenograft tumors, making it a valuable tool for cancer research.
Chemical Information
| Catalog Num | A65420 |
|---|---|
| M. Wt | 398.38 |
| Formula | C22H17F3N2O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1195786-61-8 |
| Synonyms | |
| SMILES | OCCN(C1=C2C=C(C=C1)NC(C3=CC=CC=C3C(F)(F)F)=O)C4=C2C=CC=C4 |
Biological Activity
| Description | AF3485 is an inhibitor of the human microsomal prostaglandin E synthase-1 (mPGES-1), demonstrating significant antitumor activity both in vitro and in vivo. This compound effectively targets tumor-associated angiogenesis by lowering prostaglandin E2 (PGE2) levels, inhibiting epidermal growth factor receptor (EGFR) signaling, and decreasing the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-2 (FGF-2). Subchronic administration of AF3485 has been shown to reduce tumor growth in mice with human A431 xenograft tumors, making it a valuable tool for cancer research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
