Product Data Sheet
EC1169
Catalog No. A65438
EC1169 is a PSMA-targeted maytansinoid conjugate that selectively binds to prostate-specific membrane antigen (PSMA). This compound delivers the cytotoxic maytansinoid B hydrazide payload directly to PSMA-positive tumor cells, demonstrating significant antitumor activity while sparing PSMA-negative cells. In preclinical models, EC1169 promotes complete recovery in mice with PSMA-positive tumors, exhibiting a favorable safety profile without inducing body weight loss or major organ damage. This reagent is valuable for research focused on prostate cancer and other PSMA-expressing malignancies.
Chemical Information
| Catalog Num | A65438 |
|---|---|
| M. Wt | 1790.00 |
| Formula | C78H112N14O28S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1610413-96-1 |
| Synonyms | |
| SMILES | O=C([C@@H]1N(CCCC1)C)N[C@@H]([C@@H](C)CC)C(N(COC(CCC)=O)[C@@H](C(C)C)C[C@H](C2=NC(C(N[C@H](C[C@H](C)C(NNC(OCCSSC[C@@H](C(O)=O)NC([C@H](CC(O)=O)NC([C@H](CC(O)=O)NC(CC3=CC=C(C=C3)CNC(NCCCC[C@@H](C(O)=O)NC(N[C@H](C(O)=O)CCC(O)=O)=O)=O)=O)=O)=O)=O)=O)CC4=CC=C(C=C4)O)=O)=CS2)OC(C)=O)=O |
Biological Activity
| Description | EC1169 is a PSMA-targeted maytansinoid conjugate that selectively binds to prostate-specific membrane antigen (PSMA). This compound delivers the cytotoxic maytansinoid B hydrazide payload directly to PSMA-positive tumor cells, demonstrating significant antitumor activity while sparing PSMA-negative cells. In preclinical models, EC1169 promotes complete recovery in mice with PSMA-positive tumors, exhibiting a favorable safety profile without inducing body weight loss or major organ damage. This reagent is valuable for research focused on prostate cancer and other PSMA-expressing malignancies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
