Product Data Sheet
SK1-I
Catalog No. A65525
SK1-I is a competitive inhibitor of sphingosine kinase 1 (SPHK1) with an isozyme-specific mechanism, exhibiting a Ki value of 10 μM. This compound selectively targets SPHK1 without affecting other kinases such as PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ, or CamK2β. SK1-I is noted for its ability to enhance autophagy and exhibits potential antitumor activity, making it a valuable reagent for cancer research and studies involving lipid metabolism.
Chemical Information
| Catalog Num | A65525 |
|---|---|
| M. Wt | 277.40 |
| Formula | C17H27NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1072443-89-0 |
| Synonyms | BML-258 |
| SMILES | OC[C@H]([C@H](/C=C/C1=CC=C(C=C1)CCCCC)O)NC |
Biological Activity
| Description | SK1-I is a competitive inhibitor of sphingosine kinase 1 (SPHK1) with an isozyme-specific mechanism, exhibiting a Ki value of 10 μM. This compound selectively targets SPHK1 without affecting other kinases such as PKCα, PKCδ, PKA, AKT1, ERK1, EGFR, CDK2, IKKβ, or CamK2β. SK1-I is noted for its ability to enhance autophagy and exhibits potential antitumor activity, making it a valuable reagent for cancer research and studies involving lipid metabolism. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
