Product Data Sheet
Amgen-23
Catalog No. A65527
Amgen-23 is a selective inhibitor of sphingosine kinase 1 (SPHK1), exhibiting an IC50 value of 20 nM, while demonstrating lower potency against sphingosine kinase 2 (SPHK2) with an IC50 of 1.6 µM. This compound is valuable for investigating the role of SPHK1 in cancer biology and may facilitate the development of novel anticancer therapies. Its use in research settings can enhance the understanding of sphingolipid metabolism and cellular signaling pathways in tumorigenesis.
Chemical Information
| Catalog Num | A65527 |
|---|---|
| M. Wt | 478.43 |
| Formula | C23H25Cl2N3O2S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1448706-15-7 |
| Synonyms | |
| SMILES | ClC(C=C1C2=CSC(NC3=CC=C(C=C3)CCN4[C@H](C[C@H](CC4)O)CO)=N2)=C(C=C1)Cl |
Biological Activity
| Description | Amgen-23 is a selective inhibitor of sphingosine kinase 1 (SPHK1), exhibiting an IC50 value of 20 nM, while demonstrating lower potency against sphingosine kinase 2 (SPHK2) with an IC50 of 1.6 µM. This compound is valuable for investigating the role of SPHK1 in cancer biology and may facilitate the development of novel anticancer therapies. Its use in research settings can enhance the understanding of sphingolipid metabolism and cellular signaling pathways in tumorigenesis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
