Product Data Sheet
SLM6031434 hydrochloride
Catalog No. A65529
SLM6031434 hydrochloride is a selective inhibitor of sphingosine kinase 2 (SphK2), exhibiting an IC50 of 0.4 μM. This compound is known for its anti-fibrotic properties, primarily by promoting sphingosine accumulation and enhancing Smad7 expression. Research indicates that SLM6031434 effectively reduces tubulointerstitial fibrosis in a unilateral ureteral obstruction (UUO) mouse model, making it valuable for investigations into proteinuric kidney diseases and chronic kidney disease (CKD).
Chemical Information
| Catalog Num | A65529 |
|---|---|
| M. Wt | 489.96 |
| Formula | C22H31ClF3N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1897379-34-8 |
| Synonyms | |
| SMILES | N=C(N1[C@H](C2=NC(C(C=C3)=CC(C(F)(F)F)=C3OCCCCCCCC)=NO2)CCC1)N.Cl |
Biological Activity
| Description | SLM6031434 hydrochloride is a selective inhibitor of sphingosine kinase 2 (SphK2), exhibiting an IC50 of 0.4 μM. This compound is known for its anti-fibrotic properties, primarily by promoting sphingosine accumulation and enhancing Smad7 expression. Research indicates that SLM6031434 effectively reduces tubulointerstitial fibrosis in a unilateral ureteral obstruction (UUO) mouse model, making it valuable for investigations into proteinuric kidney diseases and chronic kidney disease (CKD). |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
