Product Data Sheet
SLR080811
Catalog No. A65536
SLR080811 is a selective inhibitor of sphingosine kinase 2 (SphK2), with an inhibition constant (Ki) of 1.3 μM and approximately 10-fold selectivity over sphingosine kinase 1 (SphK1) with a Ki of 12 μM. This compound effectively reduces sphingosine 1-phosphate (S1P) levels in vitro, while also promoting a SphK1-dependent increase in S1P in in vivo mouse models. SLR080811 is suitable for research applications related to cancer and fibrosis, offering valuable insights into the role of sphingosine kinases in these disease processes.
Chemical Information
| Catalog Num | A65536 |
|---|---|
| M. Wt | 369.50 |
| Formula | C21H31N5O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1449765-65-4 |
| Synonyms | |
| SMILES | N=C(N1[C@@H](C2=NC(C3=CC=C(C=C3)CCCCCCCC)=NO2)CCC1)N |
Biological Activity
| Description | SLR080811 is a selective inhibitor of sphingosine kinase 2 (SphK2), with an inhibition constant (Ki) of 1.3 μM and approximately 10-fold selectivity over sphingosine kinase 1 (SphK1) with a Ki of 12 μM. This compound effectively reduces sphingosine 1-phosphate (S1P) levels in vitro, while also promoting a SphK1-dependent increase in S1P in in vivo mouse models. SLR080811 is suitable for research applications related to cancer and fibrosis, offering valuable insights into the role of sphingosine kinases in these disease processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
