Product Data Sheet
SR-717 free acid
Catalog No. A65563
SR-717 free acid is a non-nucleotide STING agonist that demonstrates effective activation in immune responses, exhibiting EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 wild-type and cGAS knockout cell lines, respectively. This compound serves as a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, enhancing antitumor activity through stimulation of the STING pathway. Its potential applications in cancer immunotherapy and the study of innate immunity make it a valuable tool for researchers in the field of immunology.
Chemical Information
| Catalog Num | A65563 |
|---|---|
| M. Wt | 345.26 |
| Formula | C15H9F2N5O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2375420-34-9 |
| Synonyms | |
| SMILES | O=C(O)C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O |
Biological Activity
| Description | SR-717 free acid is a non-nucleotide STING agonist that demonstrates effective activation in immune responses, exhibiting EC50 values of 2.1 μM and 2.2 μM in ISG-THP1 wild-type and cGAS knockout cell lines, respectively. This compound serves as a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic, enhancing antitumor activity through stimulation of the STING pathway. Its potential applications in cancer immunotherapy and the study of innate immunity make it a valuable tool for researchers in the field of immunology. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
