Product Data Sheet
2A3
Catalog No. A65661
2A3 is a binding reagent targeting CEACAM5 and CEACAM6, exhibiting catalytic glucuronidation activity on specific substrates, including 1-naphthol. It demonstrates significant cytotoxic effects against cancer cells with high expression of these antigens, particularly in pancreatic and breast cancers. When used in CAR T cell applications or as a standalone agent, 2A3 stimulates cytokine release and degranulation, effectively inhibiting tumor growth in vivo. This reagent serves as a valuable tool in the investigation of immunotherapeutic strategies for targeting malignant tumors that overexpress CEACAM5 and CEACAM6.
Chemical Information
| Catalog Num | A65661 |
|---|---|
| M. Wt | 188.19 |
| Formula | C9H8N4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2765091-45-8 |
| Synonyms | |
| SMILES | O=C(C1=CC=CN=C1N)N2C=NC=C2 |
Biological Activity
| Description | 2A3 is a binding reagent targeting CEACAM5 and CEACAM6, exhibiting catalytic glucuronidation activity on specific substrates, including 1-naphthol. It demonstrates significant cytotoxic effects against cancer cells with high expression of these antigens, particularly in pancreatic and breast cancers. When used in CAR T cell applications or as a standalone agent, 2A3 stimulates cytokine release and degranulation, effectively inhibiting tumor growth in vivo. This reagent serves as a valuable tool in the investigation of immunotherapeutic strategies for targeting malignant tumors that overexpress CEACAM5 and CEACAM6. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
