Product Data Sheet
HDM2004
Catalog No. A65762
HDM2004 is a selective inhibitor of HPK1, demonstrating potent activity with an IC50 of 1.89 nM. This compound is orally bioavailable and effectively penetrates the blood-brain barrier, exhibiting notable anticancer activity against colon cancer. Additionally, HDM2004 shows synergistic effects when used in combination with anti-PD-L1 in syngeneic mouse models, making it a valuable tool for research into colon cancer therapies.
Chemical Information
| Catalog Num | A65762 |
|---|---|
| M. Wt | 485.62 |
| Formula | C28H35N7O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2953016-30-1 |
| Synonyms | |
| SMILES | CCN(CC1)CCC1N(N=C2)C=C2C3=CNC4=C3N=C(C5=CC=C(N6C[C@@H](C)O[C@H](C)C6)C=C5)C=N4 |
Biological Activity
| Description | HDM2004 is a selective inhibitor of HPK1, demonstrating potent activity with an IC50 of 1.89 nM. This compound is orally bioavailable and effectively penetrates the blood-brain barrier, exhibiting notable anticancer activity against colon cancer. Additionally, HDM2004 shows synergistic effects when used in combination with anti-PD-L1 in syngeneic mouse models, making it a valuable tool for research into colon cancer therapies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
