Product Data Sheet

HPK1-IN-35

Catalog No. A65771

main product photo
HPK1-IN-35 is a potent and selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound effectively reduces the phosphorylation of SLP76 while promoting the secretion of interleukin-2 (IL-2). HPK1-IN-35 is particularly valuable for research in T cell activation and immune response modulation.
Chemical Information
Catalog NumA65771
M. Wt584.69
FormulaC30H32N8O3S
Purity>98%
Storageat -20 °C 3 years (powder form); at -20 °C 6 months (Solution base)
CAS No.2935903-77-6
Synonyms
SMILESCOC1=C(C=C2CN(CCC2=C1)C)NC3=NC4=C(C(NC5=CC=CC=C5S(=O)(N(C)C)=O)=N3)C(C6=CC=CN=C6)=CN4
Biological Activity
DescriptionHPK1-IN-35 is a potent and selective inhibitor of HPK1, demonstrating an IC50 value of 3.5 nM. This compound effectively reduces the phosphorylation of SLP76 while promoting the secretion of interleukin-2 (IL-2). HPK1-IN-35 is particularly valuable for research in T cell activation and immune response modulation.
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