Product Data Sheet
PROTAC HPK1 Degrader-6
Catalog No. A65775
PROTAC HPK1 Degrader-6 is a potent PROTAC compound designed to selectively target and degrade the HPK1 protein, exhibiting an IC50 of less than 50 nM. This compound facilitates the investigation of HPK1's role in leukemia and other related disorders. By employing the dual binding mechanism to HPK1 and the E3 ligase CRBN, it serves as a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy.
Chemical Information
| Catalog Num | A65775 |
|---|---|
| M. Wt | 709.84 |
| Formula | C41H43N9O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3099168-12-1 |
| Synonyms | |
| SMILES | O=C(N1)N(C2=CC=C(C3CCN(C4CN(C5=CC=C(NC6=NC=C7C=CC(C8=CN=C9OCCNC9=C8C)=CC7=N6)C=C5)C4)CC3)C=C2C)CCC1=O |
Biological Activity
| Description | PROTAC HPK1 Degrader-6 is a potent PROTAC compound designed to selectively target and degrade the HPK1 protein, exhibiting an IC50 of less than 50 nM. This compound facilitates the investigation of HPK1's role in leukemia and other related disorders. By employing the dual binding mechanism to HPK1 and the E3 ligase CRBN, it serves as a valuable tool for researchers exploring targeted protein degradation as a therapeutic strategy. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
