Product Data Sheet
MEK-IN-7
Catalog No. A65813
MEK-IN-7 is a potent, orally available, and selective inhibitor of MEK1, demonstrating an IC50 of 29.62 nM. This compound effectively inhibits the proliferation of HT29 and A375 cancer cell lines, with IC50 values of 0.62 nM and 0.40 nM, respectively. Additionally, MEK-IN-7 has been shown to suppress tumor growth in HL-29 xenograft mouse models, making it a valuable reagent for research in melanoma and colon cancer.
Chemical Information
| Catalog Num | A65813 |
|---|---|
| M. Wt | 649.47 |
| Formula | C27H25FIN3O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2256822-22-5 |
| Synonyms | |
| SMILES | O=C1OC2=C(C(NC3=CC=C(C=C3F)I)=C1C)C(N(C4CC4)C(C)=C2C5=C(C)C(NS(C)(=O)=O)=CC=C5)=O |
Biological Activity
| Description | MEK-IN-7 is a potent, orally available, and selective inhibitor of MEK1, demonstrating an IC50 of 29.62 nM. This compound effectively inhibits the proliferation of HT29 and A375 cancer cell lines, with IC50 values of 0.62 nM and 0.40 nM, respectively. Additionally, MEK-IN-7 has been shown to suppress tumor growth in HL-29 xenograft mouse models, making it a valuable reagent for research in melanoma and colon cancer. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
