Product Data Sheet
BAY-866
Catalog No. A65819
BAY-866 is an allosteric inhibitor of MEK1, exhibiting an IC50 of 14 nM. This compound effectively inhibits cell proliferation in A375 (BRAF) and HCT116 (K-Ras) cell lines, with respective IC50 values of 13 nM and 277 nM. Additionally, BAY-866 demonstrates anti-tumor activity in K-Ras-mutated A549 xenograft models, making it a valuable tool for research in cancer biology and targeted therapies.
Chemical Information
| Catalog Num | A65819 |
|---|---|
| M. Wt | 596.29 |
| Formula | C19H13F4IN4O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1836185-18-2 |
| Synonyms | |
| SMILES | O=C(C1=C(C=C(C(F)=C1NC2=CC=C(C=C2F)I)F)OC3=CC=C(C(NS(=O)(N)=O)=C3)F)N |
Biological Activity
| Description | BAY-866 is an allosteric inhibitor of MEK1, exhibiting an IC50 of 14 nM. This compound effectively inhibits cell proliferation in A375 (BRAF) and HCT116 (K-Ras) cell lines, with respective IC50 values of 13 nM and 277 nM. Additionally, BAY-866 demonstrates anti-tumor activity in K-Ras-mutated A549 xenograft models, making it a valuable tool for research in cancer biology and targeted therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
