Product Data Sheet
SOS1-IN-21
Catalog No. A65865
SOS1-IN-21 is a potent inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 plays a critical role in the activation of KRAS by promoting GDP-GTP exchange. SOS1-IN-21 demonstrates significant antiproliferative effects, exhibiting IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell lines. Additionally, it shows substantial antitumor activity in the Mia Paca-2 xenograft model, making it a valuable tool for research on KRAS mutant tumors, including pancreatic cancer.
Chemical Information
| Catalog Num | A65865 |
|---|---|
| M. Wt | 493.52 |
| Formula | C25H30F3N3O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2767633-04-3 |
| Synonyms | |
| SMILES | CC(O)(C)C(F)(F)C1=CC=CC([C@H](NC2=C3C=C(OCCOC)C(OC)=CC3=NC(C)=N2)C)=C1F |
Biological Activity
| Description | SOS1-IN-21 is a potent inhibitor of son of Sevenless 1 (SOS1) with an IC50 of 15 nM. As a guanine nucleotide exchange factor (GEF), SOS1 plays a critical role in the activation of KRAS by promoting GDP-GTP exchange. SOS1-IN-21 demonstrates significant antiproliferative effects, exhibiting IC50 values of 16 nM in NCI-H358 and 17 nM in Mia Paca-2 cell lines. Additionally, it shows substantial antitumor activity in the Mia Paca-2 xenograft model, making it a valuable tool for research on KRAS mutant tumors, including pancreatic cancer. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
