Product Data Sheet
PPZ2
Catalog No. A66058
PPZ2 is a diacylglycerol (DAG)-activated agonist of the TRPC3, TRPC6, and TRPC7 calcium channels. It promotes neuronal development and survival through its ability to elicit cation currents and calcium ion (Ca(2+)) influx in cultured central neurons in a dose-dependent manner. PPZ2 induces BDNF-like neurite outgrowth and provides neuroprotection, effects that are negated following TRPC channel knockdown or inhibition. Additionally, PPZ2 enhances the activation of the calcium-dependent transcription factor cAMP response element binding protein, highlighting the role of calcium signaling in its neurotrophic actions.
Chemical Information
| Catalog Num | A66058 |
|---|---|
| M. Wt | 367.48 |
| Formula | C22H29N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 896203-18-2 |
| Synonyms | |
| SMILES | O=C(NC1=CC=CC=C1OCC)CN2CCN(C3=CC=CC(C)=C3C)CC2 |
Biological Activity
| Description | PPZ2 is a diacylglycerol (DAG)-activated agonist of the TRPC3, TRPC6, and TRPC7 calcium channels. It promotes neuronal development and survival through its ability to elicit cation currents and calcium ion (Ca(2+)) influx in cultured central neurons in a dose-dependent manner. PPZ2 induces BDNF-like neurite outgrowth and provides neuroprotection, effects that are negated following TRPC channel knockdown or inhibition. Additionally, PPZ2 enhances the activation of the calcium-dependent transcription factor cAMP response element binding protein, highlighting the role of calcium signaling in its neurotrophic actions. |
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Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
