Product Data Sheet
Crisugabalin
Catalog No. A66073
Crisugabalin is a selective ligand targeting the α2δ subunit of voltage-gated calcium channels, exhibiting an IC50 of 3.96 nM in rat models. This compound effectively inhibits the binding of [3H]gabapentin to the α2δ subunit, leading to reduced calcium influx and decreased neuronal excitability, ultimately impairing nociceptive transmission. Crisugabalin has demonstrated efficacy in alleviating mechanical allodynia and various pain models, including neuropathic and inflammatory pain. Its applications are relevant in research contexts involving chronic pain syndromes such as diabetic neuropathy, fibromyalgia, and postherpetic neuralgia.
Chemical Information
| Catalog Num | A66073 |
|---|---|
| M. Wt | 209.28 |
| Formula | C12H19NO2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2209104-84-5 |
| Synonyms | HSK16149 |
| SMILES | O=C(O)C[C@@]1(CN)[C@](C2)([H])[C@@]3([H])C[C@]2([H])CC[C@@]13[H] |
Biological Activity
| Description | Crisugabalin is a selective ligand targeting the α2δ subunit of voltage-gated calcium channels, exhibiting an IC50 of 3.96 nM in rat models. This compound effectively inhibits the binding of [3H]gabapentin to the α2δ subunit, leading to reduced calcium influx and decreased neuronal excitability, ultimately impairing nociceptive transmission. Crisugabalin has demonstrated efficacy in alleviating mechanical allodynia and various pain models, including neuropathic and inflammatory pain. Its applications are relevant in research contexts involving chronic pain syndromes such as diabetic neuropathy, fibromyalgia, and postherpetic neuralgia. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
