Product Data Sheet
MONIRO-1
Catalog No. A66092
MONIRO-1 is a selective inhibitor of T-type and N-type calcium channels, demonstrating IC50 values of 34 µM, 3.3 µM, 1.7 µM, and 7.2 µM against hCav2.2, hCav3.1, hCav3.2, and hCav3.3, respectively, while exhibiting minimal activity against L-type calcium channels. Its ability to modulate calcium influx makes MONIRO-1 a valuable tool for research into pain pathways and epilepsy mechanisms. This compound is instrumental for studies focused on the pharmacological modulation of calcium channels in neuronal excitability.
Chemical Information
| Catalog Num | A66092 |
|---|---|
| M. Wt | 458.91 |
| Formula | C23H24ClFN4O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1909225-94-0 |
| Synonyms | |
| SMILES | N/C(N)=N\CCCOC1=CC=C(C=C1)C(NC2=C(C=CC=C2)OC3=CC=C(C=C3)F)=O.Cl |
Biological Activity
| Description | MONIRO-1 is a selective inhibitor of T-type and N-type calcium channels, demonstrating IC50 values of 34 µM, 3.3 µM, 1.7 µM, and 7.2 µM against hCav2.2, hCav3.1, hCav3.2, and hCav3.3, respectively, while exhibiting minimal activity against L-type calcium channels. Its ability to modulate calcium influx makes MONIRO-1 a valuable tool for research into pain pathways and epilepsy mechanisms. This compound is instrumental for studies focused on the pharmacological modulation of calcium channels in neuronal excitability. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
