Product Data Sheet
Ethacrynic acid D5
Catalog No. A66172
Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications.
Chemical Information
| Catalog Num | A66172 |
|---|---|
| M. Wt | 308.17 |
| Formula | C13H7D5Cl2O4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1330052-59-9 |
| Synonyms | |
| SMILES | O=C(O)COC1=CC=C(C(C(C([2H])([2H])C([2H])([2H])[2H])=C)=O)C(Cl)=C1Cl |
Biological Activity
| Description | Ethacrynic acid D5 is a deuterium-labeled analog of Ethacrynic acid, primarily targeting glutathione S-transferases (GSTs). This compound exhibits diuretic properties and serves as a potent inhibitor of the NF-kB signaling pathway, with implications in modulating leukotriene formation. Additionally, it inhibits L-type voltage-dependent and store-operated calcium channels, contributing to the relaxation of airway smooth muscle cells. Ethacrynic acid D5 also demonstrates anti-inflammatory effects, evidenced by its ability to reduce retinoid-induced ear edema in murine models, making it valuable in related research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
