Product Data Sheet
(R)-Niguldipine
Catalog No. A66186
(R)-Niguldipine is a calcium channel antagonist that effectively blocks calcium channels, leading to vasodilation by reducing the influx of calcium ions across cell membranes. It demonstrates potent inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, with a pID50 of 9.93, and displays high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10). (R)-Niguldipine also significantly lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55), making it a valuable compound for research in cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias.
Chemical Information
| Catalog Num | A66186 |
|---|---|
| M. Wt | 609.71 |
| Formula | C36H39N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 120054-86-6 |
| Synonyms | |
| SMILES | O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@H]1C2=CC([N+]([O-])=O)=CC=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3 |
Biological Activity
| Description | (R)-Niguldipine is a calcium channel antagonist that effectively blocks calcium channels, leading to vasodilation by reducing the influx of calcium ions across cell membranes. It demonstrates potent inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, with a pID50 of 9.93, and displays high affinity for calcium channel binding sites on guinea pig skeletal muscle membranes (Ki of 8.10). (R)-Niguldipine also significantly lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55), making it a valuable compound for research in cardiovascular diseases such as hypertension, angina pectoris, and arrhythmias. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
