Product Data Sheet
(S)-Lercanidipine
Catalog No. A66212
(S)-Lercanidipine is a calcium channel blocker that exhibits antihypertensive and neuroprotective activities. It effectively reduces oxidative stress and has been shown to protect auditory sensory hair cells from noise-induced damage. In vitro studies demonstrate that (S)-Lercanidipine enhances cell viability, particularly at lower concentrations, and significantly lowers the hearing threshold in mice following noise exposure. Its antioxidant properties are characterized by an increase in the expression of antioxidant enzyme genes and a decrease in oxidative enzyme gene expression, suggesting its potential for mitigating noise-induced hearing loss and preserving outer hair cell viability.
Chemical Information
| Catalog Num | A66212 |
|---|---|
| M. Wt | 611.73 |
| Formula | C36H41N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 185197-71-1 |
| Synonyms | |
| SMILES | O=C(OC(C)(CN(C)CCC(C1=CC=CC=C1)C2=CC=CC=C2)C)C3=C(NC(C)=C([C@@H]3C4=CC=CC([N+]([O-])=O)=C4)C(OC)=O)C |
Biological Activity
| Description | (S)-Lercanidipine is a calcium channel blocker that exhibits antihypertensive and neuroprotective activities. It effectively reduces oxidative stress and has been shown to protect auditory sensory hair cells from noise-induced damage. In vitro studies demonstrate that (S)-Lercanidipine enhances cell viability, particularly at lower concentrations, and significantly lowers the hearing threshold in mice following noise exposure. Its antioxidant properties are characterized by an increase in the expression of antioxidant enzyme genes and a decrease in oxidative enzyme gene expression, suggesting its potential for mitigating noise-induced hearing loss and preserving outer hair cell viability. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
