Product Data Sheet
RQ-00311651
Catalog No. A66219
RQ-00311651 is a selective T-type calcium channel antagonist that predominantly targets the Cav3.2 isoform, which is implicated in neuropathic and visceral pain modulation. This compound effectively inhibits T currents in HEK293 cells expressing human Cav3.1 and Cav3.2, as well as reducing calcium signaling induced by elevated potassium levels. Additionally, RQ-00311651 demonstrates antiallergic effects and has shown efficacy in preclinical models, including reduction of acute pancreatitis and cystitis in mice following administration via oral or intraperitoneal routes. This compound offers significant potential for research in pain management and related pathological conditions.
Chemical Information
| Catalog Num | A66219 |
|---|---|
| M. Wt | 405.37 |
| Formula | C19H18F3N5O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1257116-00-9 |
| Synonyms | |
| SMILES | O=C(N[C@H](C)C1=NC=C(N=C1)OCC(F)(F)F)[C@@H]2[C@H](C2)C3=NC4=CC=CC=C4N3 |
Biological Activity
| Description | RQ-00311651 is a selective T-type calcium channel antagonist that predominantly targets the Cav3.2 isoform, which is implicated in neuropathic and visceral pain modulation. This compound effectively inhibits T currents in HEK293 cells expressing human Cav3.1 and Cav3.2, as well as reducing calcium signaling induced by elevated potassium levels. Additionally, RQ-00311651 demonstrates antiallergic effects and has shown efficacy in preclinical models, including reduction of acute pancreatitis and cystitis in mice following administration via oral or intraperitoneal routes. This compound offers significant potential for research in pain management and related pathological conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
