Product Data Sheet
CPU-228
Catalog No. A66232
CPU-228 is a complex class III antiarrhythmic agent primarily targeting the rapid component of the delayed rectifier potassium channel (IKr) and L-type calcium channel (ICa,L). It exhibits concentration-dependent inhibition of ICa,L with an IC50 of 0.909 μM. Biological assays demonstrate that CPU-228 generates negative inotropic effects and induces a mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atrial tissues. Additionally, CPU-228 is effective in reducing the incidence of torsades de pointes in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats, making it a valuable tool for research on arrhythmias and cardiac electrophysiology.
Chemical Information
| Catalog Num | A66232 |
|---|---|
| M. Wt | 426.53 |
| Formula | C23H26N2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 446877-42-5 |
| Synonyms | |
| SMILES | O=C(N(CCOC1=CC=CC=2C=CC=CC12)CCC3=CC=C(C=C3)NS(=O)(=O)C)C |
Biological Activity
| Description | CPU-228 is a complex class III antiarrhythmic agent primarily targeting the rapid component of the delayed rectifier potassium channel (IKr) and L-type calcium channel (ICa,L). It exhibits concentration-dependent inhibition of ICa,L with an IC50 of 0.909 μM. Biological assays demonstrate that CPU-228 generates negative inotropic effects and induces a mild, non-frequency-dependent prolongation of the effective refractory period (ERP) in isolated left atrial tissues. Additionally, CPU-228 is effective in reducing the incidence of torsades de pointes in anesthetized rabbits and inhibits ischemia/reperfusion-induced arrhythmias in rats, making it a valuable tool for research on arrhythmias and cardiac electrophysiology. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
