Product Data Sheet
RWJ 22108
Catalog No. A66252
RWJ 22108 is a bronchoselective calcium channel blocker that inhibits calcium influx in smooth muscle cells, demonstrating an IC50 value of 5.7 nM in the calcium-dependent contraction of canine bronchiolar smooth muscle. This compound is primarily utilized in research applications focused on respiratory physiology and the study of bronchial hyper-reactivity. Its specificity for bronchial tissues makes it a valuable tool in exploring mechanisms of airway relaxation and potential therapeutic interventions for respiratory disorders.
Chemical Information
| Catalog Num | A66252 |
|---|---|
| M. Wt | 533.05 |
| Formula | C27H30ClFN2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 112769-37-6 |
| Synonyms | |
| SMILES | O=C(OCCN(CC1=CC=CC=C1)C)C2=C(NC(CCCC3)=C(C2C4=C(C=CC=C4Cl)F)S3(=O)=O)C |
Biological Activity
| Description | RWJ 22108 is a bronchoselective calcium channel blocker that inhibits calcium influx in smooth muscle cells, demonstrating an IC50 value of 5.7 nM in the calcium-dependent contraction of canine bronchiolar smooth muscle. This compound is primarily utilized in research applications focused on respiratory physiology and the study of bronchial hyper-reactivity. Its specificity for bronchial tissues makes it a valuable tool in exploring mechanisms of airway relaxation and potential therapeutic interventions for respiratory disorders. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
