Product Data Sheet
S-312
Catalog No. A66268
S-312 is a calcium antagonist characterized by a bicyclic dihydrothienopyridine structure. This compound effectively relaxes helical strips of isolated rabbit arteries that have been pre-contracted with high potassium depolarization. S-312 acts as a competitive inhibitor of calcium-induced contractions in depolarized basilar and femoral arteries, and it also prolongs AV nodal conduction time in Langendorff-perfused isolated rabbit hearts. Additionally, S-312 demonstrates vasculoselectivity, particularly targeting cerebral vessels, making it a valuable tool for cardiovascular research applications.
Chemical Information
| Catalog Num | A66268 |
|---|---|
| M. Wt | 386.46 |
| Formula | C20H22N2O4S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 120004-07-1 |
| Synonyms | |
| SMILES | O=C(C1=C(C)NC2=C(C1C3=CC([N+]([O-])=O)=CC=C3)C(CC(C)C)=CS2)OC |
Biological Activity
| Description | S-312 is a calcium antagonist characterized by a bicyclic dihydrothienopyridine structure. This compound effectively relaxes helical strips of isolated rabbit arteries that have been pre-contracted with high potassium depolarization. S-312 acts as a competitive inhibitor of calcium-induced contractions in depolarized basilar and femoral arteries, and it also prolongs AV nodal conduction time in Langendorff-perfused isolated rabbit hearts. Additionally, S-312 demonstrates vasculoselectivity, particularly targeting cerebral vessels, making it a valuable tool for cardiovascular research applications. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
