Product Data Sheet
Adenophostin A
Catalog No. A66275
Adenophostin A is a potent modulator of inositol 1,4,5-trisphosphate receptors (IP3) that functions as a calcium (Ca2+) releaser, exhibiting an IC50 of 1.3 nM and an EC50 of 1.4 nM in rat models. This compound effectively stimulates Ca2+ release from intracellular stores and microsomes, inhibits the binding of [3H]IP3 to plasma membrane receptors, and activates chloride channels. Notably, Adenophostin A is resistant to phosphorylation and dephosphorylation by metabolic enzymes, thereby sustaining its activity and enhancing cytoplasmic Ca2+ levels in vascular smooth muscle cells. This reagent is highly relevant for research on hemorrhagic shock and related physiological studies.
Chemical Information
| Catalog Num | A66275 |
|---|---|
| M. Wt | 669.32 |
| Formula | C16H26N5O18P3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 149091-92-9 |
| Synonyms | |
| SMILES | O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O[C@@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)OP(O)(O)=O)OP(O)(O)=O)O)CO |
Biological Activity
| Description | Adenophostin A is a potent modulator of inositol 1,4,5-trisphosphate receptors (IP3) that functions as a calcium (Ca2+) releaser, exhibiting an IC50 of 1.3 nM and an EC50 of 1.4 nM in rat models. This compound effectively stimulates Ca2+ release from intracellular stores and microsomes, inhibits the binding of [3H]IP3 to plasma membrane receptors, and activates chloride channels. Notably, Adenophostin A is resistant to phosphorylation and dephosphorylation by metabolic enzymes, thereby sustaining its activity and enhancing cytoplasmic Ca2+ levels in vascular smooth muscle cells. This reagent is highly relevant for research on hemorrhagic shock and related physiological studies. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
