Product Data Sheet
(-)-Niguldipine hydrochloride ((R)-Niguldipine hydrochloride)
Catalog No. A66337
(-)-Niguldipine hydrochloride is a calcium channel antagonist that inhibits calcium influx across cell membranes, leading to vasodilation. Its biological activity includes the inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, demonstrating a pID50 of 9.93, as well as high affinity for calcium channel binding sites in guinea pig skeletal muscle membranes with a Ki of 8.10. Additionally, (-)-Niguldipine hydrochloride effectively lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55) and has potential applications in treating cardiovascular conditions such as hypertension, angina pectoris, and arrhythmias.
Chemical Information
| Catalog Num | A66337 |
|---|---|
| M. Wt | 646.17 |
| Formula | C36H40ClN3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 113145-70-3 |
| Synonyms | (R)-Niguldipine hydrochloride |
| SMILES | O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3.Cl |
Biological Activity
| Description | (-)-Niguldipine hydrochloride is a calcium channel antagonist that inhibits calcium influx across cell membranes, leading to vasodilation. Its biological activity includes the inhibition of U-46619-induced coronary artery contraction in guinea pig Langendorff hearts, demonstrating a pID50 of 9.93, as well as high affinity for calcium channel binding sites in guinea pig skeletal muscle membranes with a Ki of 8.10. Additionally, (-)-Niguldipine hydrochloride effectively lowers blood pressure in spontaneously hypertensive rats (pED30 of 5.55) and has potential applications in treating cardiovascular conditions such as hypertension, angina pectoris, and arrhythmias. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
