Product Data Sheet
8-Br-7-CH-cADPR
Catalog No. A66376
8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) functions as a potent cADPR antagonist. It exhibits partial inhibition of calcium elevation induced by sTIR dimerization, making it valuable in studies related to calcium signaling pathways. Furthermore, 8-Br-7-CH-cADPR has been shown to significantly reduce axon degeneration caused by Paclitaxel treatment, providing insights into neuroprotective mechanisms and potential therapeutic applications in neurodegenerative research.
Chemical Information
| Catalog Num | A66376 |
|---|---|
| M. Wt | 619.21 |
| Formula | C16H21BrN4O13P2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 189876-06-0 |
| Synonyms | 7-Deaza-8-bromo-cADPR; 7-Deaza-8-bromo-cyclic ADP ribose |
| SMILES | N=C1C(C=C(Br)N2[C@H]3[C@H](O)[C@H](O)[C@@H](COP4(O)=O)O3)=C2N=CN1[C@H]5[C@H](O)[C@H](O)[C@@H](COP(O)(O4)=O)O5 |
Biological Activity
| Description | 8-Br-7-CH-cADPR (7-Deaza-8-bromo-cADPR) functions as a potent cADPR antagonist. It exhibits partial inhibition of calcium elevation induced by sTIR dimerization, making it valuable in studies related to calcium signaling pathways. Furthermore, 8-Br-7-CH-cADPR has been shown to significantly reduce axon degeneration caused by Paclitaxel treatment, providing insights into neuroprotective mechanisms and potential therapeutic applications in neurodegenerative research. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
