Product Data Sheet
SB-237376 free base
Catalog No. A66401
SB-237376 free base is a potent inhibitor of potassium and calcium channels, primarily targeting the rapidly activating delayed rectifier potassium current I(Kr) with an IC50 of 0.42 μM. Additionally, at elevated concentrations, it effectively blocks the L-type calcium current I(Ca,L). In studies utilizing rabbit ventricular models, SB-237376 free base has been shown to induce early afterdepolarizations (EADs) at a concentration of 3 µM. This compound presents a lower proarrhythmic risk compared to other known I(Kr) inhibitors, making it valuable for investigations into arrhythmia-related conditions.
Chemical Information
| Catalog Num | A66401 |
|---|---|
| M. Wt | 387.43 |
| Formula | C20H25N3O5 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 179258-59-4 |
| Synonyms | |
| SMILES | O=C(NCCCNCCC1=CC=C(OC)C(OC)=C1)C2=CC=C([N+]([O-])=O)C=C2 |
Biological Activity
| Description | SB-237376 free base is a potent inhibitor of potassium and calcium channels, primarily targeting the rapidly activating delayed rectifier potassium current I(Kr) with an IC50 of 0.42 μM. Additionally, at elevated concentrations, it effectively blocks the L-type calcium current I(Ca,L). In studies utilizing rabbit ventricular models, SB-237376 free base has been shown to induce early afterdepolarizations (EADs) at a concentration of 3 µM. This compound presents a lower proarrhythmic risk compared to other known I(Kr) inhibitors, making it valuable for investigations into arrhythmia-related conditions. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
