Product Data Sheet
SRI-41315
Catalog No. A66451
SRI-41315 is a CFTR (cystic fibrosis transmembrane conductance regulator) activator that induces a prolonged pause at stop codons and suppresses premature termination codons (PTCs) associated with cystic fibrosis. This compound restores CFTR expression and function in both immortalized and primary human bronchial epithelial cells by decreasing the levels of the termination factor eRF1. Additionally, SRI-41315 enhances aminoglycoside-mediated readthrough, resulting in synergistic increases in CFTR activity, making it a valuable tool for research into cystic fibrosis and related therapies.
Chemical Information
| Catalog Num | A66451 |
|---|---|
| M. Wt | 357.41 |
| Formula | C22H19N3O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1613509-49-1 |
| Synonyms | |
| SMILES | O=C1C2=C(N(C)C(N=C(C3CCC3)N4C5=CC=CC=C5)=C1C4=O)C=CC=C2 |
Biological Activity
| Description | SRI-41315 is a CFTR (cystic fibrosis transmembrane conductance regulator) activator that induces a prolonged pause at stop codons and suppresses premature termination codons (PTCs) associated with cystic fibrosis. This compound restores CFTR expression and function in both immortalized and primary human bronchial epithelial cells by decreasing the levels of the termination factor eRF1. Additionally, SRI-41315 enhances aminoglycoside-mediated readthrough, resulting in synergistic increases in CFTR activity, making it a valuable tool for research into cystic fibrosis and related therapies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
