Product Data Sheet
Ivacaftor-d9
Catalog No. A66453
Ivacaftor-d9 is a potent CFTR modulator that enhances CFTR function, demonstrating an EC50 value of 255 nM for potentiation in G551D/F508del human bronchial epithelial cells. As a deuterated analog of Ivacaftor, it exhibits improved stability and pharmacokinetic properties, making it a valuable tool for cystic fibrosis research. Ivacaftor-d9 is suitable for studies aimed at understanding CFTR modulation and its implications in therapeutic development for cystic fibrosis.
Chemical Information
| Catalog Num | A66453 |
|---|---|
| M. Wt | 401.55 |
| Formula | C24H19D9N2O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1413431-07-8 |
| Synonyms | VX-770-d9 |
| SMILES | CC(C)(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C(C=C1NC(C2=CNC(C=CC=C3)=C3C2=O)=O)O)C |
Biological Activity
| Description | Ivacaftor-d9 is a potent CFTR modulator that enhances CFTR function, demonstrating an EC50 value of 255 nM for potentiation in G551D/F508del human bronchial epithelial cells. As a deuterated analog of Ivacaftor, it exhibits improved stability and pharmacokinetic properties, making it a valuable tool for cystic fibrosis research. Ivacaftor-d9 is suitable for studies aimed at understanding CFTR modulation and its implications in therapeutic development for cystic fibrosis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
