Product Data Sheet
CFTR corrector 12
Catalog No. A66474
CFTR Corrector 12 (compound 17C) is a bithiazole derivative that acts as a CFTR corrector by promoting the proper folding of defective CFTR mutants. This compound enhances chloride transport across the plasma membrane, making it beneficial for studies involving cystic fibrosis and related disorders. Additionally, CFTR Corrector 12 has been shown to recover α-sarcoglycan (α-SG) levels in mutant cells, indicating its potential in therapeutic approaches targeting CFTR-related pathologies.
Chemical Information
| Catalog Num | A66474 |
|---|---|
| M. Wt | 436.98 |
| Formula | C19H21ClN4O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 958941-60-1 |
| Synonyms | |
| SMILES | O=C(C(C)(C)C)NC1=NC(C)=C(C2=CSC(NC3=CC(Cl)=CC=C3OC)=N2)S1 |
Biological Activity
| Description | CFTR Corrector 12 (compound 17C) is a bithiazole derivative that acts as a CFTR corrector by promoting the proper folding of defective CFTR mutants. This compound enhances chloride transport across the plasma membrane, making it beneficial for studies involving cystic fibrosis and related disorders. Additionally, CFTR Corrector 12 has been shown to recover α-sarcoglycan (α-SG) levels in mutant cells, indicating its potential in therapeutic approaches targeting CFTR-related pathologies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
