Product Data Sheet
GLPG-3221
Catalog No. A66483
GLPG-3221 is a potent, orally active corrector of cystic fibrosis transmembrane conductance regulator (CFTR), exhibiting an EC50 value of 105 nM. This compound plays a crucial role in restoring CFTR function, making it significant for the treatment of cystic fibrosis. Its primary application lies in research focused on therapies aimed at enhancing CFTR activity and improving chloride transport in epithelial cells.
Chemical Information
| Catalog Num | A66483 |
|---|---|
| M. Wt | 578.62 |
| Formula | C30H37F3N2O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2222264-64-2 |
| Synonyms | |
| SMILES | O=C(O)[C@H]1N(C([C@@H]2CCCCO2)=O)[C@@H](C3=CC=CC=C3C)[C@@H](OCC4=CC(C(F)(F)F)=CN=C4OC)[C@@H]1C(C)(C)C |
Biological Activity
| Description | GLPG-3221 is a potent, orally active corrector of cystic fibrosis transmembrane conductance regulator (CFTR), exhibiting an EC50 value of 105 nM. This compound plays a crucial role in restoring CFTR function, making it significant for the treatment of cystic fibrosis. Its primary application lies in research focused on therapies aimed at enhancing CFTR activity and improving chloride transport in epithelial cells. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
