Product Data Sheet
ARN23765
Catalog No. A66486
ARN23765 is a CFTR corrector specifically designed to target the F508del mutation. With an EC50 of 38 pM in human bronchial epithelial cells, ARN23765 enhances the maturation and membrane expression of F508del-CFTR, thereby improving ion transport and secretion. This compound plays a significant role in addressing the underlying pathological mechanisms associated with cystic fibrosis, making it a valuable tool for research in therapeutic interventions for this condition.
Chemical Information
| Catalog Num | A66486 |
|---|---|
| M. Wt | 615.50 |
| Formula | C30H22F5N3O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 2244458-40-8 |
| Synonyms | |
| SMILES | OC(C1=CC=C(C=C1)O[C@H]2CCCC3=C2N(N=C3C(F)(F)F)C4=CC(C(N(C)C5=CC6=C(OC(F)(F)O6)C=C5)=O)=CC=C4)=O |
Biological Activity
| Description | ARN23765 is a CFTR corrector specifically designed to target the F508del mutation. With an EC50 of 38 pM in human bronchial epithelial cells, ARN23765 enhances the maturation and membrane expression of F508del-CFTR, thereby improving ion transport and secretion. This compound plays a significant role in addressing the underlying pathological mechanisms associated with cystic fibrosis, making it a valuable tool for research in therapeutic interventions for this condition. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
