Product Data Sheet
Tezacaftor-d6
Catalog No. A66507
Tezacaftor-d6 is a deuterium-labeled variant of Tezacaftor, a CFTR corrector designed to facilitate the proper trafficking of the F508del CFTR protein to the cell surface. Its primary mechanism involves correcting defects associated with cystic fibrosis (CF), particularly in patients homozygous for the CFTR Phe508del mutation. While Tezacaftor enhances CFTR protein presence, the co-administration with Ivacaftor, a CFTR potentiator, further improves channel activity, demonstrating significant therapeutic potential. This reagent is essential for studying CFTR modulation and the development of combination therapies for cystic fibrosis management.
Chemical Information
| Catalog Num | A66507 |
|---|---|
| M. Wt | 526.53 |
| Formula | C26H21D6F3N2O6 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1961280-94-3 |
| Synonyms | VX-661-d6 |
| SMILES | FC1=C(NC(C2(CC2)C3=CC=C4OC(OC4=C3)(F)F)=O)C=C5C(N(C[C@H](CO)O)C(C(C([2H])([2H])[2H])(CO)C([2H])([2H])[2H])=C5)=C1 |
Biological Activity
| Description | Tezacaftor-d6 is a deuterium-labeled variant of Tezacaftor, a CFTR corrector designed to facilitate the proper trafficking of the F508del CFTR protein to the cell surface. Its primary mechanism involves correcting defects associated with cystic fibrosis (CF), particularly in patients homozygous for the CFTR Phe508del mutation. While Tezacaftor enhances CFTR protein presence, the co-administration with Ivacaftor, a CFTR potentiator, further improves channel activity, demonstrating significant therapeutic potential. This reagent is essential for studying CFTR modulation and the development of combination therapies for cystic fibrosis management. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
