Product Data Sheet
NA-014
Catalog No. A66569
NA-014 is a selective positive allosteric modulator (PAM) of the excitatory amino acid transporter 2 (EAAT2), exhibiting an EC50 of 3 nM. This compound enhances the transport activity of EAAT2, which is crucial for regulating glutamate levels in the synaptic cleft. NA-014 is valuable for research into neurodegenerative diseases and synaptic dysfunction, providing insights into therapeutic strategies that target glutamate homeostasis.
Chemical Information
| Catalog Num | A66569 |
|---|---|
| M. Wt | 380.46 |
| Formula | C22H25FN4O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 3041127-59-4 |
| Synonyms | |
| SMILES | O=C(NCCC1=CC=C(F)C=C1)C(C2=CC=C(C#N)C=C2)N3CCN(C)CC3 |
Biological Activity
| Description | NA-014 is a selective positive allosteric modulator (PAM) of the excitatory amino acid transporter 2 (EAAT2), exhibiting an EC50 of 3 nM. This compound enhances the transport activity of EAAT2, which is crucial for regulating glutamate levels in the synaptic cleft. NA-014 is valuable for research into neurodegenerative diseases and synaptic dysfunction, providing insights into therapeutic strategies that target glutamate homeostasis. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
