Product Data Sheet
Saclofen
Catalog No. A66595
Saclofen is a competitive antagonist of the GABAB receptor, exhibiting an IC50 value of 7.8 μM. It demonstrates weak antagonistic activity towards the GABAB1b and GABAB2 heterodimeric receptors. Saclofen effectively inhibits Baclofen binding to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts. Additionally, it has shown anti-inflammatory and analgesic effects in preclinical models. This makes Saclofen a valuable tool for investigating GABAB receptor functions and related biological processes.
Chemical Information
| Catalog Num | A66595 |
|---|---|
| M. Wt | 249.72 |
| Formula | C9H12ClNO3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 125464-42-8 |
| Synonyms | |
| SMILES | O=S(CC(CN)C1=CC=C(Cl)C=C1)(O)=O |
Biological Activity
| Description | Saclofen is a competitive antagonist of the GABAB receptor, exhibiting an IC50 value of 7.8 μM. It demonstrates weak antagonistic activity towards the GABAB1b and GABAB2 heterodimeric receptors. Saclofen effectively inhibits Baclofen binding to rat cerebellar membranes and blocks Baclofen-induced circadian phase shifts. Additionally, it has shown anti-inflammatory and analgesic effects in preclinical models. This makes Saclofen a valuable tool for investigating GABAB receptor functions and related biological processes. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
