Product Data Sheet
AZD7325
Catalog No. A66600
AZD7325 is a potent and orally active partial positive allosteric modulator (PAM) of the GABAA receptor, specifically targeting the α2 and α3 subtypes (Ki=0.3 nM and 1.3 nM, respectively), while exhibiting reduced antagonistic activity at the α1 and α5 subtypes. It serves as a valuable tool for research applications related to anxiety disorders and Dravet syndrome. Additionally, AZD7325 acts as a moderate inducer of CYP1A2 and a potent inducer of CYP3A4 in vitro, making it relevant for studies on drug metabolism and interactions.
Chemical Information
| Catalog Num | A66600 |
|---|---|
| M. Wt | 354.38 |
| Formula | C19H19FN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 942437-37-8 |
| Synonyms | |
| SMILES | O=C(C1=NN=C2C(C3=C(OC)C=CC=C3F)=CC=CC2=C1N)NCCC |
Biological Activity
| Description | AZD7325 is a potent and orally active partial positive allosteric modulator (PAM) of the GABAA receptor, specifically targeting the α2 and α3 subtypes (Ki=0.3 nM and 1.3 nM, respectively), while exhibiting reduced antagonistic activity at the α1 and α5 subtypes. It serves as a valuable tool for research applications related to anxiety disorders and Dravet syndrome. Additionally, AZD7325 acts as a moderate inducer of CYP1A2 and a potent inducer of CYP3A4 in vitro, making it relevant for studies on drug metabolism and interactions. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
