Product Data Sheet
Darigabat
Catalog No. A66607
Darigabat is a selective positive allosteric modulator (PAM) targeting GABAA receptors, specifically the α2, α3, and α5 subtypes. This compound exhibits high affinity for GABAA receptors with K_i values of 2.9 nM for α2 and 21 nM for α3, while demonstrating significantly lower affinity for α4 and α6 subunits. Darigabat effectively penetrates the blood-brain barrier and possesses anxiolytic properties, indicating its potential use in treating conditions such as anxiety and epilepsy.
Chemical Information
| Catalog Num | A66607 |
|---|---|
| M. Wt | 440.49 |
| Formula | C22H21FN4O3S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1614245-70-3 |
| Synonyms | PF-06372865; CVL-865 |
| SMILES | CCN1C2=NN=CC(C(C=C3)=CC(C(C=CC([S](CC)(=O)=O)=C4)=C4OC)=C3F)=C2N=C1 |
Biological Activity
| Description | Darigabat is a selective positive allosteric modulator (PAM) targeting GABAA receptors, specifically the α2, α3, and α5 subtypes. This compound exhibits high affinity for GABAA receptors with K_i values of 2.9 nM for α2 and 21 nM for α3, while demonstrating significantly lower affinity for α4 and α6 subunits. Darigabat effectively penetrates the blood-brain barrier and possesses anxiolytic properties, indicating its potential use in treating conditions such as anxiety and epilepsy. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
