Product Data Sheet
MRK-898
Catalog No. A66642
MRK-898 is an orally active modulator of the GABA(A) receptor, selectively binding to the α1, α2, α3, and α5 subunits with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. This compound is significant for distinguishing between the sedative effects mediated by α1-containing receptors and the anxiolytic properties associated with α2- and/or α3-containing subtypes. MRK-898 is valuable for research investigating the therapeutic potential for anxiety and sleep disorders through GABAergic modulation.
Chemical Information
| Catalog Num | A66642 |
|---|---|
| M. Wt | 400.30 |
| Formula | C20H9F5N4 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 461450-30-6 |
| Synonyms | |
| SMILES | N#CC1=CC(F)=CC=C1C2=C(F)C=CC(C3=CN=C4N=C(C(F)(F)F)C=CN43)=C2 |
Biological Activity
| Description | MRK-898 is an orally active modulator of the GABA(A) receptor, selectively binding to the α1, α2, α3, and α5 subunits with Ki values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. This compound is significant for distinguishing between the sedative effects mediated by α1-containing receptors and the anxiolytic properties associated with α2- and/or α3-containing subtypes. MRK-898 is valuable for research investigating the therapeutic potential for anxiety and sleep disorders through GABAergic modulation. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
