Product Data Sheet
Tracazolate hydrochloride
Catalog No. A66653
Tracazolate hydrochloride is a potent modulator of the GABAA receptor, specifically exhibiting selectivity towards the β3 subunit. It enhances GABAA receptor activity, demonstrating effective potentiation in α1β1γ2s (EC50=13.2 μM) and α1β3γ2 (EC50=1.5 μM) configurations. With its significant anxiolytic and anticonvulsant properties, Tracazolate hydrochloride serves as a valuable tool for research in neurological and psychiatric disorders, elucidating the role of GABAA receptor modulation in therapeutic contexts.
Chemical Information
| Catalog Num | A66653 |
|---|---|
| M. Wt | 340.85 |
| Formula | C16H25ClN4O2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1135210-68-2 |
| Synonyms | ICI 136753 hydrochloride |
| SMILES | O=C(C1=C(C)N=C(N(CC)N=C2)C2=C1NCCCC)OCC.[H]Cl |
Biological Activity
| Description | Tracazolate hydrochloride is a potent modulator of the GABAA receptor, specifically exhibiting selectivity towards the β3 subunit. It enhances GABAA receptor activity, demonstrating effective potentiation in α1β1γ2s (EC50=13.2 μM) and α1β3γ2 (EC50=1.5 μM) configurations. With its significant anxiolytic and anticonvulsant properties, Tracazolate hydrochloride serves as a valuable tool for research in neurological and psychiatric disorders, elucidating the role of GABAA receptor modulation in therapeutic contexts. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
