Product Data Sheet
Furosemide-d5
Catalog No. A66674
Furosemide-d5 is a deuterium-labeled derivative of furosemide, primarily targeting the Na+/K+/2Cl- cotransporters, NKCC1 and NKCC2. This compound acts as a potent loop diuretic, exhibiting significant biological activity in the management of conditions such as congestive heart failure, hypertension, and edema. Additionally, furosemide-d5 can function as a GABAA receptor antagonist, demonstrating enhanced selectivity for α6-containing receptors. It serves as a valuable tool for biochemical research and pharmacokinetic studies involving furosemide.
Chemical Information
| Catalog Num | A66674 |
|---|---|
| M. Wt | 335.77 |
| Formula | C12H6D5ClN2O5S |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 1189482-35-6 |
| Synonyms | |
| SMILES | OC(C1=C(C=C(C(S(N)(=O)=O)=C1)Cl)NC([2H])([2H])C2=C([2H])C([2H])=C([2H])O2)=O |
Biological Activity
| Description | Furosemide-d5 is a deuterium-labeled derivative of furosemide, primarily targeting the Na+/K+/2Cl- cotransporters, NKCC1 and NKCC2. This compound acts as a potent loop diuretic, exhibiting significant biological activity in the management of conditions such as congestive heart failure, hypertension, and edema. Additionally, furosemide-d5 can function as a GABAA receptor antagonist, demonstrating enhanced selectivity for α6-containing receptors. It serves as a valuable tool for biochemical research and pharmacokinetic studies involving furosemide. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
