Product Data Sheet
TP003
Catalog No. A66693
TP003 is a non-selective agonist at the benzodiazepine site of the GABAA receptor, exhibiting EC50 values of 20.3 nM for α1β2γ2, 10.6 nM for α2β3γ2, 3.24 nM for α3β3γ2, and 5.64 nM for α5β2γ2. This compound demonstrates significant anxiolytic activity primarily through interaction with the α2 GABAA receptor subtype. TP003 is valuable for research into anxiety disorders and other neuropharmacological applications, providing insights into GABAA receptor-mediated anxiolysis.
Chemical Information
| Catalog Num | A66693 |
|---|---|
| M. Wt | 407.39 |
| Formula | C23H16F3N3O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 628690-75-5 |
| Synonyms | |
| SMILES | N#CC1=CC(F)=CC=C1C2=CC(C3=CN=C4C(F)=C(C(C)(O)C)C=CN43)=CC=C2F |
Biological Activity
| Description | TP003 is a non-selective agonist at the benzodiazepine site of the GABAA receptor, exhibiting EC50 values of 20.3 nM for α1β2γ2, 10.6 nM for α2β3γ2, 3.24 nM for α3β3γ2, and 5.64 nM for α5β2γ2. This compound demonstrates significant anxiolytic activity primarily through interaction with the α2 GABAA receptor subtype. TP003 is valuable for research into anxiety disorders and other neuropharmacological applications, providing insights into GABAA receptor-mediated anxiolysis. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
