Product Data Sheet
Delta3,5-cholestadien-7-one
Catalog No. A66732
Delta3,5-cholestadien-7-one is an oxysterol that functions as a negative allosteric modulator of GABAA receptors. It effectively reduces GABA-induced currents in HEK cells expressing GABAA receptor subunits α1β1γ2 and α4β3γ2, with IC50 values of 1.5 µM and 1 µM, respectively. Additionally, Delta3,5-cholestadien-7-one attenuates GABA-induced depolarization in both peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion neurons, making it valuable for research on pain perception and sensory signaling.
Chemical Information
| Catalog Num | A66732 |
|---|---|
| M. Wt | 382.62 |
| Formula | C27H42O |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 567-72-6 |
| Synonyms | |
| SMILES | O=C1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCCC(C)C)(CC[C@]2([H])[C@@]4(C(C=CCC4)=C1)C)C |
Biological Activity
| Description | Delta3,5-cholestadien-7-one is an oxysterol that functions as a negative allosteric modulator of GABAA receptors. It effectively reduces GABA-induced currents in HEK cells expressing GABAA receptor subunits α1β1γ2 and α4β3γ2, with IC50 values of 1.5 µM and 1 µM, respectively. Additionally, Delta3,5-cholestadien-7-one attenuates GABA-induced depolarization in both peptidergic and non-peptidergic nociceptors, C-LTMRs, and cold thermosensors in isolated mouse dorsal root ganglion neurons, making it valuable for research on pain perception and sensory signaling. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
