Product Data Sheet
TB-21007
Catalog No. A66744
TB-21007 is a potent inverse agonist targeting the α5 subunit of the GABAA receptor, exhibiting Ki values of 1.6 nM, 20 nM, 16 nM, and 20 nM for the α5, α1, α2, and α3 subtypes, respectively. This compound demonstrates significant brain penetration and is shown to enhance cognitive function in preclinical models, making it a valuable tool for research into cognitive disorders and neuropharmacology. Its selective action on α5-containing GABAA receptors positions it as a promising candidate for investigations into memory and learning.
Chemical Information
| Catalog Num | A66744 |
|---|---|
| M. Wt | 339.50 |
| Formula | C15H17NO2S3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 207306-50-1 |
| Synonyms | |
| SMILES | O=C1CC(C)(C)CC2=C(C3=NC=CS3)SC(SCCO)=C21 |
Biological Activity
| Description | TB-21007 is a potent inverse agonist targeting the α5 subunit of the GABAA receptor, exhibiting Ki values of 1.6 nM, 20 nM, 16 nM, and 20 nM for the α5, α1, α2, and α3 subtypes, respectively. This compound demonstrates significant brain penetration and is shown to enhance cognitive function in preclinical models, making it a valuable tool for research into cognitive disorders and neuropharmacology. Its selective action on α5-containing GABAA receptors positions it as a promising candidate for investigations into memory and learning. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
