Product Data Sheet
EF-1502
Catalog No. A66748
EF-1502 is a selective inhibitor of GABA transporters, specifically targeting GAT1 and BGT1. This compound demonstrates significant anti-epileptic activity, especially when combined with Tiagabine, enhancing seizure suppression. In contrast, co-administration with THIP resulted in reduced efficacy and dyskinesia, indicating a distinct mechanism of action. EF-1502 thus serves as a valuable tool for research into GABAergic modulation and its implications in epilepsy treatment strategies.
Chemical Information
| Catalog Num | A66748 |
|---|---|
| M. Wt | 414.58 |
| Formula | C22H26N2O2S2 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 684645-54-3 |
| Synonyms | |
| SMILES | OC1=NOC2=C1C(CCC2)N(C)CC/C=C(C3=C(C=CS3)C)\C4=C(C=CS4)C |
Biological Activity
| Description | EF-1502 is a selective inhibitor of GABA transporters, specifically targeting GAT1 and BGT1. This compound demonstrates significant anti-epileptic activity, especially when combined with Tiagabine, enhancing seizure suppression. In contrast, co-administration with THIP resulted in reduced efficacy and dyskinesia, indicating a distinct mechanism of action. EF-1502 thus serves as a valuable tool for research into GABAergic modulation and its implications in epilepsy treatment strategies. |
|---|
RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
