Product Data Sheet
GMA-839
Catalog No. A66774
GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. This compound demonstrates potent anxiolytic-like activity, exhibiting significant dose-dependent effects in various animal models, with an effective oral dosage of 1.6 mg/kg. Notably, GMA-839 has been shown to enhance punished responding in both squirrel monkeys and pigeons. These characteristics position GMA-839 as a valuable tool for research into anxiolytic drug development.
Chemical Information
| Catalog Num | A66774 |
|---|---|
| M. Wt | 388.46 |
| Formula | C21H31F3O3 |
| Purity | >98% |
| Storage | at -20 °C 3 years (powder form); at -20 °C 6 months (Solution base) |
| CAS No. | 162882-76-0 |
| Synonyms | WAY 141839; Co 2-6749 |
| SMILES | FC(F)(F)[C@]1(CC[C@@]2([C@]3(CC[C@@]4([C@H](CC[C@]4([C@@]3(CC[C@@]2(C1)[H])[H])[H])C(CO)=O)C)[H])[H])O |
Biological Activity
| Description | GMA-839 is a selective modulator of the γ-aminobutyric acid A receptor (GABAA) with an IC50 value of 230 nM. This compound demonstrates potent anxiolytic-like activity, exhibiting significant dose-dependent effects in various animal models, with an effective oral dosage of 1.6 mg/kg. Notably, GMA-839 has been shown to enhance punished responding in both squirrel monkeys and pigeons. These characteristics position GMA-839 as a valuable tool for research into anxiolytic drug development. |
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RETURN POLICY
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
Adooq’s Unconditional Return Policy ensures a smooth online shopping experience for our customers. If you are in any way unsatisfied with your purchase, you may return any item(s) within 7 days of receiving it. In the event of product quality issues, either protocol related or product related problems, you may return any item(s) within 365 days from the original purchase date. Please follow the instructions below when returning products.
SHIPPING AND STORAGE
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
Adooq products are transported at room temperature. If you receive the product at room temperature, please rest assured, the Adooq Quality Inspection Department has conducted experiments to verify that the normal temperature placement of one month will not affect the biological activity of powder products. After collecting, please store the product according to the requirements described in the datasheet. Most Adooq products are stable under the recommended conditions.
